The image above represents the expertise, skills and passion of our members. They cover a vast array of research areas, from computational genomics to inpatient hyperglycemia prevention, islet biology to vascular therapeutics, stem-cell-based high content screening to adipogenesis, and novel obesity provider platforms to diabetes technologies. By bringing all of these skills and passions into the same conversation, we can make a difference in metabolic disease.
Openings for Postdoctoral Positions
Several postdoctoral positions are available at the Weill Center for Metabolic Health. Detailed information is available here.
Selected publications from center members (2022)
Selected publications from 2021
Gomez-Salinero, J. M. et al. and Rafii, S. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell Stem Cell 29, 593-609 e597 (2022).
Gu, W. et al. and Zhou, Q. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell 29, 101-115 e110 (2022).
Vandana, J. J., Lacko, L. A. and Chen, S. Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis. Cell Stem Cell 29, 873-875 (2022).
Han, Y. et al. and Chen, S. SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Circ Res 130, 963-977 (2022).
Altorki, N. K. et al. and McGraw, T. E. Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma. Cell Rep 39, 110639 (2022).
Matsui, M. et al. and Pitt, G. S. Increased Ca2+ influx through CaV1.2 drives aortic valve calcification. JCI Insight, 155569 (2022).
Krishnan, J. K. et al. and Safford, M.M. Race and Sex Differences in Mortality in Individuals with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc (2022).
Sosa, B. R., Wang, Z., Healey, J. H., Hameed, M. & Greenblatt, M. B. A Subset of Osteosarcoma Bears Markers of CXCL12-Abundant Reticular Cells. JBMR Plus 6, e10596, (2022).
Pinheiro, L. C., Reshetnyak, E., Akinyemiju, T., Phillips, E. & Safford, M. M. Social determinants of health and cancer mortality in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study. Cancer 128, 122-130 (2022).
Ghazizadeh, Z. et al. and Chen, S. A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells. iScience 25, 104153 (2022).
Zhang, X. et al. and Maxfield, F. R. Phosphatidylinositol phosphates modulate interactions between the StarD4 sterol trafficking protein and lipid membranes. J Biol Chem 298, 102058 (2022).
Khodneva, Y. et al. and Safford, M. M. Depressive Symptoms and Incident Hospitalization for Heart Failure: Findings From the REGARDS Study. J Am Heart Assoc 11, e022818 (2022).
Reading Turchioe, M. et al. and Safford, M. M. Atrial Fibrillation and Stroke Symptoms in the REGARDS Study. J Am Heart Assoc 11, e022921 (2022).
Sasset, L. et al. and Di Lorenzo, A. S1P controls endothelial sphingolipid homeostasis via ORMDL. The FASEB Journal 36 (2022).
Kulm, S., Kofman, L., Mezey, J. & Elemento, O. Simple Linear Cancer Risk Prediction Models With Novel Features Outperform Complex Approaches. JCO Clin Cancer Inform 6, e2100166 (2022).
Price, D. R. et al. and Rafii, S. Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome. Am J Pathol (2022).
Pinheiro, L. C., Soroka, O., Kern, L. M., Leonard, J. P. & Safford, M. M. Racial Disparities in Diabetes-Related Emergency Department Visits and Hospitalizations Among Cancer Survivors. JCO Oncol Pract, OP.21.00684 (2022).
Pinheiro, L. C., Soroka, O., Kern, L. M., Leonard, J. P. & Safford, M. M. Racial Disparities in Diabetes-Related Emergency Department Visits and Hospitalizations Among Cancer Survivors. JCO Oncol Pract, OP2100684 (2022).
Tchang, B. G. et al. and Shukla, A. P. Weight Loss Outcomes With Telemedicine During COVID-19. Front Endocrinol (Lausanne) 13, 793290 (2022).
Qu, H., Shewchuk, R. M., Richman, J., Andreae, L. J. & Safford, M. M. Identifying Patient Profiles for Developing Tailored Diabetes Self-Management Interventions: A Latent Class Cluster Analysis. Risk Manag Healthc Policy 15 (2022).
Pinheiro, L. C. et al. and Safford, M. M. Managing diabetes during treatment for breast cancer: oncology and primary care providers' views on barriers and facilitators. Support Care Cancer 30, 6901-6908 (2022).
Tchang, B. G., Aras, M., Wu, A., Aronne, L. J. & Shukla, A. P. Long-term weight loss maintenance with obesity pharmacotherapy: A retrospective cohort study. Obes Sci Pract 8, 320-327 (2022).
Gaglioti, A. H., Rivers, D., Ringel, J. B., Judd, S. & Safford, M. M. Individual and Neighborhood Influences on the Relationship Between Waist Circumference and Coronary Heart Disease in the REasons for Geographic and Racial Differences in Stroke Study. Prev Chronic Dis 19, E20 (2022).
Finch, A. J. et al. and Safford, M. M. Greater Social Functioning Associated With Lower Depressive Symptomatology Among Black Belt African Americans Enrolled in the Southeastern Collaboration to Improve Blood Pressure Control Study. Prim Care Companion CNS Disord 24, 21m02988 (2022).
Gu, W., Colarusso, J. L., Dame, M. K., Spence, J. R. & Zhou, Q. Rapid establishment of human colonic organoid knockout lines. STAR Protoc 3, 101308 (2022).
Upcoming center seminars
September 14, 2022 - Tracy G. Anthony, PhD, Professor of Nutritional Sciences, Rutgers
October 12, 2022 - Andrew Stewart, MD, Director of Diabetes Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai
December 14, 2022 - Guy Rutter, PhD, Chair in Cell Biology, Imperial College London