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Center for Metabolic Health

The Joan and Sanford I. Weill Center for Metabolic Health brings together scientists and clinicians across Weill Cornell Medicine and our Tri-I partners to advance the understanding of diabetes, obesity, and other metabolic diseases. Our mission is to drive breakthrough discoveries and develop new therapeutics. Directed by Dr. Laura Alonso, our investigators leverage stem cells, cellular and molecular biology, genetics, proteomics, and nutritional research to uncover the molecular mechanisms of these critical conditions. The Metabolic Phenotyping Center conducts sophisticated metabolic studies in rodent models and delivers the highest-quality assays of blood markers.

Our work is at the forefront of advances in metabolic health, including research on the biology and therapeutic use of GLP-1/GIP agonists to manage diabetes and obesity. We unite faculty across institutions to catalyze transformational team science and collaborative growth, fostering faculty and trainees to address pressing real-world challenges in metabolic health. We are proud to support 47 faculty members (20 PhDs, 18 MDs, and 7 MD-PhDs). Meet our members.

News

Ordinary fat cells in obese animals can be induced to burn energy stores, generating substantial heat, according to a preclinical study by Weill Cornell Medicine investigators.

In the study, published Feb. 23 in Nature Metabolism, the researchers showed that in fat cells called white adipocytes, high levels of fatty acids from fat stores, in the presence of a key enzyme called AAC, can trigger a process that uses fat to...

Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During their preparation for this battle, B cells transiently revert to a more flexible, or plastic, stem-cell-like state in the lymph nodes, according to a new preclinical study from Weill Cornell Medicine investigators. The results could help explain how many lymphomas develop from mature B cells rather than from stem cells, as many other cancers do, and guide researchers in...

Weill Cornell Medicine investigators have identified an early step in a cellular process that leads to inflammation in fat cells and may result in type 2 diabetes in people with obesity.

The findings, published Oct. 28 in the Journal of Clinical Investigation, show that a protein called FAM20C acts as a switch that turns on inflammation and insulin resistance in the fat cells of overweight mice. Genetic techniques to remove or...

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