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Center for Metabolic Health

The Weill Center for Metabolic Health brings together scientists and clinicians across Weill Cornell Medicine and our Tri-I partners to advance the understanding of diabetes, obesity, and other metabolic diseases. Our mission is to drive breakthrough discoveries and develop new therapeutics. Directed by Dr. Laura Alonso, our investigators leverage stem cells, cellular and molecular biology, genetics, proteomics, and nutritional research to uncover the molecular mechanisms of these critical conditions. The Metabolic Phenotyping Core conducts sophisticated metabolic studies in rodent models and delivers the highest-quality assays of blood markers. Our work is at the forefront of advances in metabolic health, including research on the biology and therapeutic use of GLP-1/GIP agonists to manage diabetes and obesity.

Our Goals

We unite faculty across institutions to catalyze transformational team science and collaborative growth, fostering faculty and trainees to address pressing real-world challenges in metabolic health.

Our Members

With expertise spanning clinical medicine, biochemistry, pharmacology, physiology, pathology, and cell biology, our investigators apply the Center’s resources to tackle today’s most urgent metabolic health issues. We are proud to support 47 faculty members (20 PhDs, 18 MDs, and 7 MD-PhDs). Click here to view members.

News

New Tool Identifies Proteins That Control Gene Activity

October 2, 2025

A new tool greatly improves scientists’ ability to identify and study proteins that regulate gene activity in cells, according to a study reported in the Proceedings of the National Academy of Sciences led by Metabolic Center Member Dr. Shuibing Chen. The technology should enable and enhance investigations in both fundamental biology and disease research.

Oral GLP-1 Drug Orforglipron Promotes Substantial Weight Loss in Clinical Trial

September 18, 2025

Patients taking an experimental oral GLP-1 drug lost significant weight and improved their heart and metabolic risk factors in a large, international, phase 3 clinical trial led by Metabolic Center Member Dr. Louis Aronne. The results from the ATTAIN-1 trial were published Sept. 17 in the New England Journal of Medicine.

NIH Funds Study of Type 1 Diabetes Development 

September 11, 2025

Metabolic Center Member Dr. Shuibing Chen will lead a project that received a four-year, $3.4 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, for a study of the details and dynamics of the autoimmune process that causes type 1 diabetes. 

Dr. Matthew Greenblatt Awarded Paul-Gallin Trailblazer Prize for Bone Stem Cell Discoveries 

August 21, 2025

Each year, the Foundation for the National Institutes of Health awards the Paul-Gallin Trailblazer Prize to an early- to mid-career physician-scientist who is translating their basic science discoveries into new ways to diagnose, prevent, treat, or cure disease or disability. This year, Metabolic Center member Dr. Matthew Greenblatt was selected by a jury of biomedical research leaders for the discovery that bone contains multiple populations of stem cells with different anatomic locations and functions. 

Interview with Dr. Louis Aronne on Bloomberg TV 

July 21, 2025

Center Member Dr. Louis Aronne joins Bloomberg TV to talk about the impact the new GLP1 weight loss drugs have had on overcoming obesity.

Study Reveals New Clues in Liver Disease Prevention

July 17, 2025

The aging liver undergoes dramatic changes in its functional organization and other key attributes, which may underpin its increasing susceptibility to disease, according to findings led by Center Member Dr. Robert Schwartz at Weill Cornell Medicine. The study, published on July 4 in Hepatology, suggest the possibility of future therapies that would block or reduce such changes to treat or prevent age-related chronic liver diseases—effectively making the liver more youthful and resilient.

2025 Excellence in Medical Education Awards

June 30, 2025

Center Member Dr. Anyanate Gwendolyne Jack receives the Innovations in Technology Award from Weill Cornell Medicine.

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Events

Weill Center for Metabolic Health Seminar

Oct 27 2025 - 12:00pm to 1:00pm

Belfer Research Building

Translational models to study human Type 1 diabetes development and therapy

Diabetes Prevention and Management

Nov 14 2025 - 11:00am to 2:00pm

525 East 68th Street New York, New York, Garden Cafe

In recognition of World Diabetes Day and National Diabetes Month, learn more about the importance of healthy eating, physical activity and other lifestyle changes to reduce the risk of developing diabetes or to manage diabetes better. Engage in fun activities about healthy eating, discover delicious and nutritious recipes, and receive personalized tips from our knowledgeable staff.