Selected publications from center members and upcoming seminars

Altorki, N. K. et al. and McGraw, T. E. Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma. Cell Rep 39, 110639 (2022).

Aronson, B. E. et al. and Apostolou, E. A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus. Dev Cell 56, 3052-3065 e3055 (2021).

Baquero, J., Tang, X. H., Scognamiglio, T. & Gudas, L. J. EZH2 knockout in oral cavity basal epithelia causes more invasive squamous cell carcinomas. Carcinogenesis 42, 1485-1495 (2021).

Duan, X. et al. and and Chen, S. An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection. Cell Rep 37, 109920 (2021).

Finch, A. J. et al. and Safford, M. M. Greater Social Functioning Associated With Lower Depressive Symptomatology Among Black Belt African Americans Enrolled in the Southeastern Collaboration to Improve Blood Pressure Control Study. Prim Care Companion CNS Disord 24, 21m02988 (2022).

Gomez-Salinero, J. M., Itkin, T. & Rafii, S. Developmental angiocrine diversification of endothelial cells for organotypic regeneration. Dev Cell 56, 3042-3051 (2021).

Gomez-Salinero, J. M. et al. and Rafii, S. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell Stem Cell 29, 593-609 e597 (2022).

Goyal, P. et al. and Safford, M. M. Clinical Characteristics and Outcomes of Adults With a History of Heart Failure Hospitalized for COVID-19. Circ Heart Fail 14, e008354 (2021).

Gu, W. et al. and Zhou, Q. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell 29, 101-115 e110 (2022).

Han, Y. et al. and Chen, S. SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Circ Res 130, 963-977 (2022).

Khodneva, Y. et al. and Safford, M. M. Depressive Symptoms and Incident Hospitalization for Heart Failure: Findings From the REGARDS Study. J Am Heart Assoc 11, e022818 (2022).

Kolin, D. A., Kulm, S. & Elemento, O. Prediction of primary venous thromboembolism based on clinical and genetic factors within the U.K. Biobank. Sci Rep 11, 21340 (2021).

Kulm, S., Kofman, L., Mezey, J. & Elemento, O. Simple Linear Cancer Risk Prediction Models With Novel Features Outperform Complex Approaches. JCO Clin Cancer Inform 6, e2100166 (2022).

Matsui, M. et al. and Pitt, G. S. Increased Ca2+ influx through CaV1.2 drives aortic valve calcification. JCI Insight, 155569 (2022).

Pinheiro, L. C., Reshetnyak, E., Akinyemiju, T., Phillips, E. & Safford, M. M. Social determinants of health and cancer mortality in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study. Cancer 128, 122-130 (2022).

Pinheiro, L. C., Soroka, O., Kern, L. M., Leonard, J. P. & Safford, M. M. Racial Disparities in Diabetes-Related Emergency Department Visits and Hospitalizations Among Cancer Survivors. JCO Oncology Practice 0, OP.21.00684 (2022).

Pinheiro, L. C., Soroka, O., Kern, L. M., Leonard, J. P. & Safford, M. M. Racial Disparities in Diabetes-Related Emergency Department Visits and Hospitalizations Among Cancer Survivors. JCO Oncol Pract, OP2100684 (2022).

Pipalia, N. H. et al. and Maxfield, F. R. HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts. J Lipid Res 62, 100114 (2021).

Reading Turchioe, M. et al. and Safford, M. M. Atrial Fibrillation and Stroke Symptoms in the REGARDS Study. J Am Heart Assoc 11, e022921 (2022).

Reiterer, M. et al. and Lo, J. C. Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell Metab 33, 2484 (2021). 

Shah, Y. et al. and Elemento, O. Pan-cancer analysis reveals molecular patterns associated with age. Cell Rep 37, 110100 (2021).

Sharma, R. B., Landa-Galvan, H. V. & Alonso, L. C. Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic beta-Cells. Diabetes 70, 2431-2443 (2021).

Snyder, J. T., Darko, C., Sharma, R. B. & Alonso, L. C. Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse beta-Cells. Front Endocrinol (Lausanne) 12, 734079 (2021).

Sosa, B. R., Wang, Z., Healey, J. H., Hameed, M. & Greenblatt, M. B. A Subset of Osteosarcoma Bears Markers of CXCL12-Abundant Reticular Cells. JBMR Plus 6, e10596, (2022).

Tang, X. H. et al. and Gudas, L. J. A retinoic acid receptor beta2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease. J Biol Chem 297, 101331 (2021).

Taylor, S. R. et al. and Goncalves, M. D. Dietary fructose improves intestinal cell survival and nutrient absorption. Nature 597, 263-267 (2021).

Tchang, B. G. et al. and Shukla, A. P. Weight Loss Outcomes With Telemedicine During COVID-19. Front Endocrinol (Lausanne) 13, 793290 (2022).

Yang, L. et al. and Chen, S. Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem Cell Reports 16, 2274-2288 (2021).